Condition: Rhegmatogenous Retinal Detachment · Sponsor: Queen's University, Belfast
Background and study aims The retina is the layer at the back of the eye that allows us to see. Sometimes, it can detach from the wall of the eye, causing a condition called rhegmatogenous retinal detachment (RRD), which leads to vision loss and requires surgery. The most common surgery for RRD is vitrectomy, but this can lead to complications like cataracts, which worsen over time and need to be removed with another surgery. Cataract surgery involves replacing the cloudy lens with a clear artificial one. Currently, it's unclear whether it's better to perform both surgeries at the same time or separately. The COMBAT study aims to find out which approach is best by comparing the outcomes of patients who have vitrectomy alone versus those who have both surgeries (vitrectomy and cataract surgery by phacoemulsification and intraocular lens \[IOL\] implantation) together. Who can participate? Adults aged 50 and older who have RRD but are not highly myopic (less than -6 diopters or an axial length of 26.5 mm or less) and have not had previous vitreoretinal surgery. Participants must be scheduled for a pars plana vitrectomy to repair their RRD. What does the study involve? Participants will be randomly assigned to one of two groups: one group will have vitrectomy first and, if needed, cataract surgery later; the other group will have both surgeries at the same time. The study will compare their vision, the number of successful retina reattachments, health related and visual relate…
This description comes directly from the study's public registry record.
Colette Jackson · +44 28 96151447 · colette.jackson@nictu.hscni.net
Always discuss trial participation with your own doctor first.
| Buckinghamshire Healthcare NHS Trust | Aylesbury, United Kingdom | Recruiting |
| Belfast Health and Social Care Trust | Belfast, United Kingdom | Recruiting |
| Sandwell and West Birmingham Hospitals NHS Trust | Birmingham, United Kingdom | Recruiting |
| Bradford Teaching Hospitals NHS Foundation Trust | Bradford, United Kingdom | Recruiting |
| University Hospitals Bristol NHS Foundation Trust | Bristol, United Kingdom | Recruiting |
| County Durham and Darlington NHS Foundation Trust | Darlington, United Kingdom | Recruiting |
| NHS Lothian | Edinburgh, United Kingdom | Not Yet Recruiting |
| NHS Greater Glasgow & Clyde | Glasgow, United Kingdom | Recruiting |
| Hull University Teaching Hospitals NHS Trust | Hull, United Kingdom | Recruiting |
| The Leeds Teaching Hospitals NHS Trust | Leeds, United Kingdom | Not Yet Recruiting |
| University Hospitals Leicester NHS Trust | Leicester, United Kingdom | Recruiting |
| Liverpool University Hospitals NHS Foundation Trust | Liverpool, United Kingdom | Recruiting |
+ 19 more locations — full list on the registry record.
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Source record: clinicaltrials.gov/study/NCT06997874