Condition: Colon Adenocarcinoma · Rectal Adenocarcinoma · Sponsor: Merck Sharp & Dohme LLC
Researchers are looking for other ways to treat locally advanced or metastatic colorectal cancer (mCRC) that is unresectable and has a gene mutation called KRAS G12C. Standard (or usual) treatments for this type of colorectal cancer may include mFOLFOX6 with or without bevacizumab. Researchers want to learn if adding calderasib (the study medicine) and cetuximab to mFOLFOX6 can treat locally advanced or mCRC with the KRAS G12C mutation. Calderasib and cetuximab are targeted therapies. The goals of this study are to learn: * About the safety of calderasib with cetuximab and mFOLFOX6 and if people tolerate the treatments * If people who receive calderasib with cetuximab and mFOLFOX6 live longer without mCRC growing or spreading compared to people who receive mFOLFOX6 with or without bevacizumab.
This description comes directly from the study's public registry record.
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| Los Angeles Hematology Oncology Medical Group ( Site 0084) | Los Angeles, California, United States | Recruiting |
| UCLA Hematology/Oncology - Santa Monica ( Site 0088) | Santa Monica, California, United States | Recruiting |
| University of Colorado Health - Harmony-Cancer Care and Hematology - Ft. Collins ( Site 0087) | Fort Collins, Colorado, United States | Recruiting |
| Rocky Mountain Cancer Centers (RMCC) ( Site 8000) | Lone Tree, Colorado, United States | Recruiting |
| Florida Cancer Specialists - South ( Site 7002) | Fort Myers, Florida, United States | Recruiting |
| Orlando Health Cancer Institute ( Site 0065) | Orlando, Florida, United States | Recruiting |
| Florida Cancer Specialists - North ( Site 7001) | St. Petersburg, Florida, United States | Recruiting |
| Florida Cancer Specialists - East ( Site 7000) | West Palm Beach, Florida, United States | Recruiting |
| Saint Alphonsus Regional Medical Center ( Site 0085) | Boise, Idaho, United States | Recruiting |
| Accellacare of Duly ( Site 2015) | Lisle, Illinois, United States | Recruiting |
| University of Iowa ( Site 0074) | Iowa City, Iowa, United States | Recruiting |
| University of Kentucky ( Site 0055) | Lexington, Kentucky, United States | Recruiting |
+ 205 more locations — full list on the registry record.
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Source record: clinicaltrials.gov/study/NCT06997497