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Study identifier: NCT06997276 Synced from ClinicalTrials.gov · July 29, 2026
● Recruiting

Effect of Hepatic Impairment on the Pharmacokinetics of Mirdametinib

Condition: Healthy · Hepatic Impairment  ·  Sponsor: SpringWorks Therapeutics, Inc., a healthcare company of Merck KGaA, Darmstadt, Germany

PhasePhase 1
Planned participants32
Who can joinAll sexes, 18 Years to 80 Years
Healthy volunteersYes

About this study

The purposes of this study are to determine: * The pharmacokinetics (the amount of study drug in your blood and how long it takes the body to get rid of it) of the study drug and its metabolites (substances produced as the body breaks down the study drug) in participants with moderate or severe liver function impairment compared to participants with normal liver function (also known as a healthy volunteer). Pharmacokinetics (or PK) is the study of how your body absorbs, breaks down, and removes a study drug. * How well the study drug is tolerated and any side effects that may occur in participants with moderate or severe liver function impairment compared to participants with normal liver function. This study is for research purposes only and is not intended to treat any medical condition.

This description comes directly from the study's public registry record.

Talk to the study team

US Medical Information  ·  888-275-7376  ·  eMediUSA@emdserono.com

Always discuss trial participation with your own doctor first.

Locations (3)

Clinical Pharmacology of MiamiMiami, Florida, United StatesRecruiting
Orlando Clinical Research CenterOrlando, Florida, United StatesRecruiting
American Research Corporation (Texas Liver Institute)San Antonio, Texas, United StatesRecruiting

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Source record: clinicaltrials.gov/study/NCT06997276