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Study identifier: NCT06996756 Synced from ClinicalTrials.gov · July 28, 2026
● Recruiting

Gene Therapy for Alpha 1- Antitrypsin Deficiency

Condition: Alpha 1-Antitrypsin Deficiency  ·  Sponsor: Weill Medical College of Cornell University

PhasePhase 1
Planned participants16
Who can joinAll sexes, 18 Years to 70 Years
Healthy volunteersNo

About this study

This is a study of gene therapy to treat alpha 1-antitrypsin (AAT) deficiency. This study aims to treat AAT deficiency with a single administration of AAV8hAAT(AVL), a gene therapy that codes for an oxidation resistant form of the AAT protein, which if safe and if efficacious, will protect the lung on a persistent basis. We hope to learn the safety/toxicity and initial evidence of efficacy of intravenous delivery of this gene therapy to alpha 1-antitrypsin deficient individuals.

This description comes directly from the study's public registry record.

Talk to the study team

Niamh Savage  ·  646-962-5527  ·  nis2049@med.cornell.edu

Sandra Hyde  ·  646-962-2672  ·  sah2003@med.cornell.edu

Always discuss trial participation with your own doctor first.

Locations (1)

WCMC Department of Genetic MedicineNew York, New York, United StatesRecruiting

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Source record: clinicaltrials.gov/study/NCT06996756