Condition: Relapsed or Refractory Aggressive B-cell Lymphoma · Sponsor: Institute of Hematology & Blood Diseases Hospital, China
This study consists of two sequential treatment phases. In the first phase, patients with r/r aggressive B-NHL receive two cycles of glofitamab ± investigator-selected agents. In the second phase, patients eligible for CAR-T monotherapy undergo FC lymphodepletion followed by CAR-T infusion (2-4×10⁶/kg), while those eligible for CAR-T+ASCT receive conditioning chemotherapy with PBSC reinfusion on day 0 and CAR-T administration (2-4×10⁶/kg) on day +3 (±1). Patients demonstrating Deauville 4-5 or ctDNA positivity at day 28 post-CAR-T infusion subsequently receive four cycles of glofitamab consolidation therapy.
This description comes directly from the study's public registry record.
WEI LIU · 86-022-23608461 · liuwei@ihcams.ac.cn
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| Institute of Hematology & Blood Diseases Hospital | Tianjin, China | Recruiting |
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Source record: clinicaltrials.gov/study/NCT06996132