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Study identifier: NCT06995664 Synced from ClinicalTrials.gov · July 29, 2026
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Partial Volume High-Dose Irradiation in Renal Cell Carcinoma for Intra-TUmoural Control ALongside Current Management

Condition: Renal Cell Carcinoma · Renal Cell Carcinoma Metastatic  ·  Sponsor: Royal Marsden NHS Foundation Trust

PhaseNA
Planned participants24
Who can joinAll sexes, 18 Years to no upper limit
Healthy volunteersNo

About this study

Prospective, randomised, feasibility study of patients with localised or metastatic renal cell carcinoma (RCC) comparing standard palliative dose radiotherapy to a high-dose hypofractionated regime. Primary aim • To demonstrate feasibility of a randomised study comparing high-dose hypofractionated radiotherapy versus standard palliative dose radiotherapy in localised or metastatic renal cell carcinoma The aim is to recruit a minimum of 24 patients; 12 to the control arm and 12 to the high-dose regime. 2 treatment arms, no placebo: * Control arm - standard palliative-dose radiotherapy, 30Gy in 10 fractions in 3Gy per fraction over 2 weeks * High-dose arm - high-dose radiotherapy, 30Gy in 5 fractions in 6Gy per fraction on alternate days/2-3 fractions a week over 2 weeks

This description comes directly from the study's public registry record.

Talk to the study team

Harshani Green  ·  020 7811 8116  ·  VIRTUAL.Trial@rmh.nhs.uk

Sijy Pillai  ·  020 7811 8116  ·  VIRTUAL.Trial@rmh.nhs.uk

Always discuss trial participation with your own doctor first.

Locations (1)

The Royal Marsden NHSFTLondon, United KingdomRecruiting

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Source record: clinicaltrials.gov/study/NCT06995664