Condition: Mechanical Ventilation · Pediatric Acute Respiratory Failure · Analgesics, Opioid · Sponsor: Weill Medical College of Cornell University
In this clinical trial, investigators want to learn more about using non-opioid pain medications for children with acute respiratory failure. Right now, doctors give these children opioids to help with pain while they are on the ventilator, but investigators don't know if this is the best way to manage their pain. Even with strong doses of opioids, more than 90% of these children still feel pain. Other pain medicines, like acetaminophen (also called Tylenol) and ketorolac (also called Toradol), are available but aren't commonly used because we don't know if they help. The goal of this clinical trial is to test if acetaminophen and/or ketorolac can improve pain control and reduce the need for stronger pain medications (opioids) in these children. To learn more about this, participants will be randomly placed in one of four study treatment groups. This means that a computer will decide by chance which group each participant is in, not the doctors running the study. Each group will receive a combination of intravenous acetaminophen, ketorolac or a harmless substance called a placebo. In this clinical trial, placebos help investigators see if the actual medications (acetaminophen and ketorolac) work better than something that doesn't contain medicine. By comparing participants who get the real medicine with those who get the placebo, investigators can find out if these medications effectively decrease pain.
This description comes directly from the study's public registry record.
Chani Traube, MD · 212-746-3056 · chr9008@med.cornell.edu
Kammy Jacobsen · kammy.jacobsen@hsc.utah.edu
Always discuss trial participation with your own doctor first.
| Arkansas Children's Hospital | Little Rock, Arkansas, United States | Recruiting |
| Children's National Hospital | Washington D.C., District of Columbia, United States | Not Yet Recruiting |
| University of Michigan | Ann Arbor, Michigan, United States | Not Yet Recruiting |
| Children's Hospital of Michigan | Detroit, Michigan, United States | Recruiting |
| University of Minnesota | Minneapolis, Minnesota, United States | Recruiting |
| Duke Children's Hospital & Health Center | Durham, North Carolina, United States | Recruiting |
| Rainbow Babies and Children's Hospital | Cleveland, Ohio, United States | Recruiting |
| Nationwide Children's Hospital | Columbus, Ohio, United States | Recruiting |
| Penn State Health/Hershey Medical Center | Hershey, Pennsylvania, United States | Recruiting |
| Children's Hospital of Philadelphia | Philadelphia, Pennsylvania, United States | Recruiting |
| University of Pittsburgh | Pittsburgh, Pennsylvania, United States | Recruiting |
| Medical University of South Carolina | Charleston, South Carolina, United States | Recruiting |
+ 3 more locations — full list on the registry record.
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Source record: clinicaltrials.gov/study/NCT06994442