Condition: Flap Monitoring · Inflammation · Thrombosis · Sponsor: Dharmais National Cancer Center Hospital
This double-blinded randomized controlled trial aims to investigate the effect of intraoperative dexmedetomidine administration on early flap viability and microvascular integrity in cancer patients undergoing elective microvascular reconstructive surgery. The primary outcome is clinical flap viability within 48 hours postoperatively, assessed using a standardized scoring system based on flap color, temperature, capillary refill time, and tissue turgor. Secondary outcomes include the evaluation of biomarkers related to endothelial glycocalyx degradation (syndecan-1), oxidative stress (SOD-1), inflammation (IL-6, IL-10), thrombosis (PAI-1), and angiogenesis (VEGF), as well as microcirculatory assessment using Sidestream Dark Field (SDF) imaging. The study is designed to determine whether dexmedetomidine improves early surgical outcomes by modulating pathophysiological processes involved in microvascular flap success.
This description comes directly from the study's public registry record.
Gardian Lukman Hakim, Anestesiologist · 81218088113 · gardian.hakim@gmail.com
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| Dharmais National Cancer Center Hospital | Jakarta, DKI Jakarta, Indonesia | Not Yet Recruiting |
| Dharmais National Cancer Center Hospital | Jakarta, DKI Jakarta, Indonesia | Recruiting |
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Source record: clinicaltrials.gov/study/NCT06993740