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Study identifier: NCT06992882 Synced from ClinicalTrials.gov · July 29, 2026
● Recruiting

A Randomized, Open-label, Multi-center Phase III Study Comparing the Efficacy of Oral Chemotherapy Combined With Trastuzumab Versus Paclitaxel Combined With Trastuzumab in the Adjuvant Treatment of HER2-positive, Lymph Node-negative Early Breast Cancer Patients(ORCHID-PLUS)

Condition: HER2-positive Breast Cancer  ·  Sponsor: Fudan University

PhasePhase 3
Planned participants2306
Who can joinFemale, 18 Years to 70 Years
Healthy volunteersNo

About this study

Although there is a certain risk of recurrence of HER2-positive small tumors, the overall prognosis is relatively good. In order to further reduce the toxicity and side effects of treatment and explore the best strategy for adjuvant therapy in patients with HER2-positive stage IA breast cancer, we designed this phase III, randomized, open-label study to evaluate the efficacy and safety of paclitaxel plus trastuzumab and capecitabine versus paclitaxel plus trastuzumab in the adjuvant treatment of patients with HER2-positive, node-negative breast cancer.

This description comes directly from the study's public registry record.

Talk to the study team

Zhimin Shao, MD  ·  +86-021-64175590  ·  zhimingshao@yahoo.com

Always discuss trial participation with your own doctor first.

Locations (1)

Fudan University Shanghai Cancer Center Shanghai, China, 200032Shanghai, Shanghai Municipality, ChinaRecruiting

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Source record: clinicaltrials.gov/study/NCT06992882