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Study identifier: NCT06989775 Synced from ClinicalTrials.gov · July 28, 2026
● Recruiting

BoxX-NoAF Clinical Trial

Condition: Post Operative Atrial Fibrillation · Atrial Fibrillation, Postoperative  ·  Sponsor: AtriCure, Inc.

PhaseNA
Planned participants960
Who can joinAll sexes, 65 Years to no upper limit
Healthy volunteersYes

About this study

Post Operative Atrial Fibrillation (POAF) is the most common complication of cardiac surgery. POAF incidence can exceed 50% depending on the patient baseline characteristics and surgery type. Patients with POAF tend to have worse acute and long-term clinical outcomes. BoxX-NoAF is a randomized trial to evaluate if prophylactic ablation and exclusion of the Left Atrial Appendage at the time of other routine cardiac surgery can reduce the incidence of post operative AF and clinical AF during long term follow up in patients who have not yet developed AF but are at risk.

This description comes directly from the study's public registry record.

Talk to the study team

BoxX-NoAF Trial Inbox  ·  1 (513) 755-4100  ·  BoxXNoAF@atricure.com

Always discuss trial participation with your own doctor first.

Locations (27)

St. Bernards Medical CenterJonesboro, Arkansas, United StatesRecruiting
Sharp Memorial HospitalSan Diego, California, United StatesRecruiting
Morton Plant Hospital - BayCare Health System, Inc.Clearwater, Florida, United StatesRecruiting
St. Joseph's Hospital - BayCare Health System, Inc.Clearwater, Florida, United StatesRecruiting
Orlando Health, Inc.Orlando, Florida, United StatesRecruiting
Sarasota Memorial HospitalSarasota, Florida, United StatesRecruiting
Emory UniversityAtlanta, Georgia, United StatesRecruiting
Piedmont HospitalAtlanta, Georgia, United StatesRecruiting
Wellstar Health SystemMarietta, Georgia, United StatesRecruiting
Northwestern Memorial HospitalChicago, Illinois, United StatesRecruiting
Norton HealthcareLouisville, Kentucky, United StatesRecruiting
MedStar Health Research InstituteBaltimore, Maryland, United StatesRecruiting

+ 15 more locations — full list on the registry record.

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Source record: clinicaltrials.gov/study/NCT06989775