Condition: Postoperative Pain · General Anesthesia · Laparoscopic Cholecystectomy · Sponsor: Wonkwang University Hospital
General anesthesia requires precise titration of inhaled anesthetics like desflurane and opioids like remifentanil to balance sedation, analgesia, and hemodynamic stability. The Analgesia/Nociception Index (ANI), derived from heart rate variability (HRV), quantifies parasympathetic tone to assess nociception-antinociception balance on a 0-100 scale, with lower values indicating nociceptive stress. ANI analyzes high-frequency HRV components, reflecting parasympathetic inhibition during painful stimuli, making it a reliable indicator of intraoperative nociception. Studies validate the utility of ANI in detecting nociceptive events during laparoscopic surgery. ANI-guided opioid titration reduces opioid consumption and stabilizes hemodynamics, enhancing perioperative outcomes.
This description comes directly from the study's public registry record.
Cheol Lee, M.D.,Ph.D · +82-1066131252 · ironyii@wku.ac.kr
Cheolhyeong Lee, M.D. · +82-10-7736-9397 · Leecheolhyeong@gmail.com
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| Wonkwang University School of Medicine Hospital | Iksan, Jeollabuk-do, South Korea | Recruiting |
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Source record: clinicaltrials.gov/study/NCT06982209