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Study identifier: NCT06982105 Synced from ClinicalTrials.gov · July 28, 2026
● Recruiting

Trimethoprim-sulfamethoxazole vs. Clindamycin for the Treatment of Children With Invasive MRSA Infections

Condition: Methicillin Resistant Staphylococcus Aureus · Osteomyelitis Acute · Septic Arthritis  ·  Sponsor: Indiana University

PhasePhase 4
Planned participants100
Who can joinAll sexes, 2 Months to 18 Years
Healthy volunteersNo

About this study

The goal of this clinical trial is to learn if trimethoprim-sulfamethoxazole (TMP-SMX) works to treat invasive infections due to methicillin-resistant Staphylococcus aureus (MRSA) in children. It will also learn about the safety of TMP-SMX in the treatment of children with invasive MRSA infections. The main questions it aims to answer are: -Is TMP-SMX effective at successfully treating children with invasive infections due to MRSA? What are the side effects of TMP-SMX in children taking it for invasive infections due to MRSA? Researchers will compare TMP-SMX to a clindamycin (a commonly prescribed antibiotic for the treatment of MRSA in children) to see if TMP-SMX works better, worse or the same as clindamycin for children with invasive infections due to MRSA. Participants will: Take TMP-SMX or clindamycin for the treatment of their invasive infection due to MRSA. Will follow up with the provider treating their invasive infection at the discretion of the treating provider. Keep a diary of their symptoms and any side effects of the medicine

This description comes directly from the study's public registry record.

Talk to the study team

Mary Stumpf  ·  317-274-8801  ·  mestumpf@iu.edu

Always discuss trial participation with your own doctor first.

Locations (1)

Riley Hospital for ChildrenIndianapolis, Indiana, United StatesRecruiting

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Source record: clinicaltrials.gov/study/NCT06982105