Condition: Sickle Cell Disease · Pregnancy Related · Sponsor: Emory University
The goal of this study is to determine if there is a positive effect of prophylactic red blood cell (RBC) transfusion of leukoreduced, ABO, Rh (D/Cc/Ee) and Kell matched blood compared to standard of care on the number of episodes of acute sickle cell disease (SCD) manifestations or pregnancy-related complications requiring acute health care encounters (acute care/ER/Hospital visits) or resulting in death over the entirety of pregnancy until 2 months post-partum in women with SCD. RBC transfusion is the only disease-modifying therapy for pregnant women with SCD, and it is considered a standard treatment option however, there exists no consensus on the role of transfusion therapy in preventing SCD-related pregnancy complications. Participants will be randomly assigned to repeated red blood cell transfusions or the standard of care. Participants will be on study for about 8-10 months (Pregnancy through 2 months post-partum).
This description comes directly from the study's public registry record.
Ross Fasano, MD · 404-712-5227 · rfasano@emory.edu
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| Grady Health System | Atlanta, Georgia, United States | Recruiting |
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Source record: clinicaltrials.gov/study/NCT06979492