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Study identifier: NCT06979440 Synced from ClinicalTrials.gov · July 29, 2026
● Recruiting

Study on the Molecular Mechanism of Berberine to Improve Type 2 Diabetes Mellitus Complicated With Depression

Condition: Diabetes-Related Complications  ·  Sponsor: Affiliated Hospital of Nantong University

PhaseN/A
Planned participants40
Who can joinAll sexes, 18 Years to 65 Years
Healthy volunteersNo

About this study

The incidence of type 2 diabetes with comorbid depression (T2DD) is notably high, characterized by prolonged disease duration and susceptibility to recurrence. The preliminary experiments identified 5-AVAB, a gut microbiota-derived metabolite, as a potential novel biomarker for T2DD progression. Given the absence of existing research in this area, it warrants in-depth investigation. The investigators plan to collect fecal and serum samples from participants with type 2 diabetes and those with T2DD to quantify 5-AVAB levels, as well as conduct in vitro gut microbiota culturing and sequencing studies.

This description comes directly from the study's public registry record.

Talk to the study team

Zhengwei Zhang, PhD  ·  15701539317  ·  zhangzhengwei95@foxmail.com

Zheng Yang, MD  ·  0513-85052230  ·  zzw3737@126.com

Always discuss trial participation with your own doctor first.

Locations (1)

Affiliated Hospital of Nantong UniversityNantong, Jiangsu, ChinaRecruiting

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Source record: clinicaltrials.gov/study/NCT06979440