Condition: HCC - Hepatocellular Carcinoma · Sponsor: RenJi Hospital
This study is designed prospectively to investigate the safety and efficacy of ABSK-011 and ABSK043 in patients with previously treated unresectable or metastatic hepatocellular carcinoma (HCC) harboring FGF19 overexpression. ABSK-011, an oral, selective FGFR4 inhibitor which can irreversibly bind to the target. ABSK043, is an orally available, selective and potent inhibitor targeting the interaction of PD-1 and PD-L1, Safety, tolerability, and preliminary efficacy of ABSK-011 or ABSK043 were explored in a phase 1 trial ABSK-011-101 (NCT04906434) and ABSK043-101 (NCT04964375) trial, respectively. This trial focuses on the efficacy of the combination of ABSK-011 and ABSK043 in patients with previously treated unresectable or metastatic HCC harboring FGF19 overexpression.
This description comes directly from the study's public registry record.
Hao Feng, Ph.D.,MD · +8615000901110 · surgeonfeng@live.com
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| Ren Ji Hospital, School of Medicine, Shanghai Jiao Tong University | Shanghai, China | Recruiting |
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Source record: clinicaltrials.gov/study/NCT06978933