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Study identifier: NCT06978257 Synced from ClinicalTrials.gov · July 28, 2026
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Digital Positive Affect Intervention Study

Condition: Mild to Moderate Anxiety and Depression  ·  Sponsor: National University of Singapore

PhaseNA
Planned participants2400
Who can joinAll sexes, 21 Years to 64 Years
Healthy volunteersNo

About this study

Anxiety and depression are highly prevalent mental health disorders that impose a significant burden on individuals and public health systems worldwide (GBD 2019 Mental Disorders Collaborators, 2022). Although many existing treatments focus on symptom reduction through targeting negative emotions, fewer interventions specifically enhance positive emotional experiences, despite growing evidence that low positive affect is a key feature of both anxiety and depression. Face-to-face psychologist-led positive affect therapy (PAT) is a promising intervention that aims to cultivate positive emotions, engagement, and meaning, potentially leading to greater improvements in emotional well-being than traditional approaches (Craske et al., 2019). However, empirical evaluations of digitally-delivered, asynchronously-coached, scalable versions of the PAT remain limited (Craske et al., 2024; Firth et al., 2017). The present study thus aims to investigate the comparative efficacy of a digital positive affect intervention (PAI) in reducing symptoms of anxiety and depression and enhancing overall mental health outcomes. We utilize a two-arm randomized controlled trial (RCT) design to investigate the effectiveness of a six-week digitally delivered positive affect intervention (vs. self-monitoring active control; Zainal \& Newman, 2023) in reducing self-reported symptoms of anxiety and depression, as well as other secondary psychosocial outcomes, including sleep quality, quality of life, and emo…

This description comes directly from the study's public registry record.

Talk to the study team

Nur Hani Zainal, Ph.D., M.A.  ·  +6565161126  ·  hanizainal@nus.edu.sg

Sarah Josephine Rajendra, B.S.  ·  +6565161126  ·  sarah.jr@nus.edu.sg

Always discuss trial participation with your own doctor first.

Locations (1)

National University of Singapore (NUS)Singapore, SingaporeRecruiting

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Source record: clinicaltrials.gov/study/NCT06978257