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Study identifier: NCT06977074 Synced from ClinicalTrials.gov · July 28, 2026
● Recruiting

PROPHET Study: ctDNA-Guided Personalized Induction Immunochemotherapy for NSCLC

Condition: Non-small Cell Lung Cancer (NSCLC)  ·  Sponsor: Sun Yat-sen University

PhasePhase 2
Planned participants83
Who can joinAll sexes, 18 Years to 75 Years
Healthy volunteersNo

About this study

The goal of this clinical trial is to evaluate the clinical value of ctDNA testing in guiding the optimization of immunochemotherapy cycles during induction treatment for resectable patients with NSCLC. The main questions it aims to answer are: * Does ctDNA clearance indicate pathological complete response? * Are additional cycles of immunochemotherapy necessary for patients who have ctDNA clearance after initial cycles of treatment? Researchers will use ctDNA dynamics to guide the cycles of induction treatment to see if some patients can avoid excessive cycles of treatment.

This description comes directly from the study's public registry record.

Talk to the study team

Ze-Rui Zhao, MD PhD  ·  +86 87343317  ·  zhaozr@sysucc.org.cn

Always discuss trial participation with your own doctor first.

Locations (1)

Sun Yat-sen University Cancer CenterGuangzhou, Guangdong, ChinaRecruiting

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Source record: clinicaltrials.gov/study/NCT06977074