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Study identifier: NCT06975787 Synced from ClinicalTrials.gov · July 29, 2026
● Recruiting

Dose Escalation Study With Bispecific Antibodies in Adult Participants With Lupus Nephritis

Condition: Lupus Nephritis (LN)  ·  Sponsor: Regeneron Pharmaceuticals

PhasePhase 1
Planned participants90
Who can joinAll sexes, 18 Years to 60 Years
Healthy volunteersNo

About this study

This study is researching a particular group of experimental drugs administered for a short period in the treatment of participants with Lupus Nephritis (LN). The main aim of the current study is to see how safe and tolerable the study drugs are in a long-term follow-up. This is a main study, called an umbrella study, which includes several independent smaller sub-studies. Each of these smaller main sub-studies tests different drugs at the same time, all aimed at treating LN. The study is looking at several other research questions, including: * What side effects may happen from taking the study drug * How much study drug is in the blood at different times * Whether the body makes antibodies against the study drug (which could make the drug less effective or could lead to side effects)

This description comes directly from the study's public registry record.

Talk to the study team

Clinical Trials Administrator  ·  844-734-6643  ·  clinicaltrials@regeneron.com

Always discuss trial participation with your own doctor first.

Locations (18)

Mayo ClinicRochester, Minnesota, United StatesRecruiting
Baylor College of MedicineHouston, Texas, United StatesRecruiting
Centre Hospitalier Universitaire (CHU) BordeauxBordeaux, New Aquitaine, FranceRecruiting
University Hospital RegensburgRegensburg, Bavaria, GermanyRecruiting
University Medical Center of the Johannes Gutenberg-University MainzMainz, GermanyRecruiting
Hallym University Sacred Heart HospitalAnyang-si, Gyeonggi-do, South KoreaRecruiting
Seoul National University HospitalSeoul, South KoreaRecruiting
Samsung Medical CenterSeoul, South KoreaRecruiting
Yonsei University College of Medicine, Severance HospitalSeoul, South KoreaRecruiting
Hospital Universitario Virgen del RocioSeville, Andalusia, SpainRecruiting
Clinica Universidad de NavarraPamplona, Navarre, SpainRecruiting
Hospital Gregorio MaranonMadrid, SpainRecruiting

+ 6 more locations — full list on the registry record.

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Source record: clinicaltrials.gov/study/NCT06975787