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Study identifier: NCT06974786 Synced from ClinicalTrials.gov · July 29, 2026
● Recruiting

Frontline T-cell Engager vs Autologous Stem Cell Transplant (ASCT) and Measurable Residual Disease (MRD)-Guided Sequential Intensification thERapy in Multiple Myeloma

Condition: Multiple Myeloma, Newly Diagnosed · Multiple Myeloma (MM)  ·  Sponsor: SCRI Development Innovations, LLC

PhasePhase 2
Planned participants100
Who can joinAll sexes, 19 Years to no upper limit
Healthy volunteersNo

About this study

This is an open-label, multi-site, Phase II randomized trial with response-adaptive design for newly diagnosed multiple myeloma (NDMM) participants who have had prior induction therapy. The primary objective of this study is to compare the rates of achieving undetectable measurable residual disease (MRD) in the bone marrow with elranatamab and daratumumab employed as post-induction consolidation and maintenance treatment (Arm A) versus autologous stem cell transplant (ASCT) followed by lenalidomide and daratumumab treatment (Arm B).

This description comes directly from the study's public registry record.

Talk to the study team

Sarah Cannon Development Innovations, LLC  ·  1-844-710-6157  ·  SCRI.InnovationsMedical@scri.com

Always discuss trial participation with your own doctor first.

Locations (11)

University of Alabama at BirminghamBirmingham, Alabama, United StatesRecruiting
Colorado Blood Cancer InstituteDenver, Colorado, United StatesRecruiting
University of IowaIowa City, Iowa, United StatesRecruiting
University of North CarolinaChapel Hill, North Carolina, United StatesRecruiting
Oncology Hematology CareCincinnati, Ohio, United StatesWithdrawn
The Ohio State University- The James Cancer Hospital and Solove Research InstituteColumbus, Ohio, United StatesRecruiting
SCRI Oncology PartnersNashville, Tennessee, United StatesRecruiting
University of Texas SouthwesternDallas, Texas, United StatesRecruiting
Virginia Oncology AssociatesNorfolk, Virginia, United StatesRecruiting
University of Wisconsin Clinical Science CenterMadison, Wisconsin, United StatesRecruiting
Medical College of WisconsinMilwaukee, Wisconsin, United StatesRecruiting

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Source record: clinicaltrials.gov/study/NCT06974786