Condition: Anterior Cruciate Ligament (ACL) Reconstruction · Sponsor: Science Valley Research Institute
Rehabilitation of knee stability and function after anterior cruciate ligament (ACL) reconstruction is slow and costly. The use of anabolic steroids, such as oxandrolone, may aid in the recovery of muscle mass and strength, as well as functional capacity. Oxandrolone, derived from dihydrotestosterone, has high anabolic activity and low androgenic activity (a 13:1 ratio), making it more effective in promoting weight gain with fewer side effects compared to other steroids. Registered by the FDA and previously by ANVISA (National Health Surveillance Agency (Brazil), it is indicated for cases of post-trauma or post-surgery weight loss. The subdermal use of oxandrolone implants is proposed to release the drug directly into the bloodstream, improving efficacy and reducing issues related to oral administration. This study evaluates the safety and tolerability of the absorbable subdermal oxandrolone implant for 24 weeks versus placebo implant in both men and women as an adjuvant treatment during rehabilitation following anterior cruciate ligament (ACL) surgical reconstruction. The serum and pharmacokinetic profile of the oxandrolone implant will be monitored.
This description comes directly from the study's public registry record.
Leandro B Agati, PhD · +55 11 4040-8670 · agati@svriglobal.com
Viviane Santana · +55 11 4040-8670 · viviane.santana@svriglobal.com
Always discuss trial participation with your own doctor first.
| Unimed Fortaleza | Fortaleza, Ceará, Brazil | Recruiting |
| Faculdade Ciências Médicas de Minas Gerais (CMMG) | Belo Horizonte, Minas Gerais, Brazil | Recruiting |
| Centro de Oncologia do Paraná | Curitiba, Paraná, Brazil | Recruiting |
| Unimed Brusque | Brusque, Santa Catarina, Brazil | Recruiting |
| Hospital e Maternidade Christóvão da Gama | Santo André, São Paulo, Brazil | Recruiting |
| Santa Casa de Santos | Santos, São Paulo, Brazil | Recruiting |
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Source record: clinicaltrials.gov/study/NCT06974526