Condition: Sepsis · Infections · Sponsor: Centre Hospitalier Universitaire de Nice
Background. Bacillus cereus group (Bc) comprises twenty-six closely related species of spore-forming environmental bacteria. Recently, increased sepsis and septic shock caused by Bc were reported in preterm neonates (PN), and the mortality rate can reach up to 30%. Using Whole Genome Sequencing (WGS) increasingly used to characterize Bc strains, The team aimed to determine an accurate identification to the species level of the strains involved in Bc invasive infections in preterm neonates in France and study their virulome profile.Methods. The team performed WGS for 40 neonate clinical strains responsible for invasive infections in PN. A screening of virulence genes was performed to characterize strains associated with poor prognosis. Clinical data were collected and all clinical and genomic findings were analyzed for risk factors for death. "
This description comes directly from the study's public registry record.
Raymond Ruimy · 04.92.03.62.20 · ruimy.r@chu-nice.fr
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| CHU NICE | Nice, Alpes Maritimes, France | Recruiting |
| CHU lille | Lille, France | Recruiting |
| AP-HM Marseille | Marseille, France | Recruiting |
| CHU Nantes | Nantes, France | Recruiting |
| CHU Nîmes | Nîmes, France | Recruiting |
| AP-HP Hôpital Robert Debré | Paris, France | Recruiting |
| Hôpital Antoine Béclère, AP-HP | Paris, France | Recruiting |
| Hôpital Cochin | Paris, France | Recruiting |
| CHU de Poitiers | Poitiers, France | Recruiting |
| CHU Rennes | Rennes, France | Recruiting |
| CHRU de Strasbourg | Strasbourg, France | Recruiting |
| CHU Toulouse | Toulouse, France | Recruiting |
+ 1 more locations — full list on the registry record.
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Source record: clinicaltrials.gov/study/NCT06973174