Condition: Rheumatoid Arthritis · Sponsor: AbbVie
Rheumatoid Arthritis (RA) is a chronic inflammatory disease causing pain, stiffness, swelling and loss of joint function. This study will evaluate the efficacy and safety of targeted therapies through a series of substudies for the treatment of moderately to severely active Rheumatoid Arthritis (RA). This study currently includes 3 substudies evaluating different treatments in participants with RA. Substudy 1 will evaluate lutikizumab monotherapy (treatment given alone) compared to placebo (looks like the study treatment but contains no medicine). Substudy 2 will evaluate ravagalimab monotherapy compared to placebo and Substudy 3 will evaluate lutikizumab and ravagalimab combination therapy (treatments given together) compared to placebo. Approximately 180 participants who have failed 1 or 2 biologic/targeted synthetic disease-modifying antirheumatic drug (tsDMARD) therapies will be enrolled in the study at approximately 65 sites worldwide. There may be higher treatment burden for participants in this trial compared to their standard of care treatment without participating in this study. Participants will attend regular visits during the study at a hospital or clinic. The effect of the treatment will be checked by medical assessments, blood tests, checking for side effects and completing questionnaires.
This description comes directly from the study's public registry record.
ABBVIE CALL CENTER · 844-663-3742 · abbvieclinicaltrials@abbvie.com
Always discuss trial participation with your own doctor first.
| Sun Valley Arthritis Center /ID# 278331 | Peoria, Arizona, United States | Recruiting |
| Arensia Research Clinic /ID# 280896 | Phoenix, Arizona, United States | Not Yet Recruiting |
| Arthritis And Rheumatism Associates (Ara) - Jonesboro /ID# 272896 | Jonesboro, Arkansas, United States | Recruiting |
| Private Practice - Dr. David S. Hallegua /ID# 277608 | Beverly Hills, California, United States | Recruiting |
| Advanced Clinical Research Center, LLC dba TriWest Research Associates /ID# 277826 | Chula Vista, California, United States | Recruiting |
| Newport Huntington Medical Group /ID# 272439 | Huntington Beach, California, United States | Recruiting |
| Cohen Medical Centers /ID# 278341 | Thousand Oaks, California, United States | Recruiting |
| The Lundquist Institute /ID# 272481 | Torrance, California, United States | Recruiting |
| Inland Rheumatology and Osteoporosis Medical Group /ID# 272449 | Upland, California, United States | Recruiting |
| Tekton Research - Fort Collins - East Harmony Road /ID# 272472 | Fort Collins, Colorado, United States | Recruiting |
| Highlands Advanced Rheumatology And Arthritis Center - Avon Park /ID# 272298 | Avon Park, Florida, United States | Recruiting |
| Clinical Research Of West Florida - Phase I Unit /ID# 272428 | Clearwater, Florida, United States | Recruiting |
+ 92 more locations — full list on the registry record.
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Source record: clinicaltrials.gov/study/NCT06972446