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Study identifier: NCT06972056 Synced from ClinicalTrials.gov · July 29, 2026
● Recruiting

Comparative Effectiveness of Migraine Preventive Medications: The APT Comparison Study

Condition: Migraine  ·  Sponsor: Mayo Clinic

PhasePhase 4
Planned participants1335
Who can joinAll sexes, 18 Years to 70 Years
Healthy volunteersNo

About this study

This goal of this study is to compare three medications used for migraine preventive treatment. This study will compare atogepant, a newer migraine preventive medication, with two older preventive medications, topiramate and propranolol. It will be determined if one works better and is more tolerable than the others. Research participants will: * Be randomly assigned to one of the three medications. * Provide information about their migraine pattern using a daily headache diary and during research visits.

This description comes directly from the study's public registry record.

Talk to the study team

Michael R Leonard, MDiv  ·  480-342-2908  ·  ARZAPTTrial@mayo.edu

Dani C Smith, M.S.  ·  Smith.Dani@Mayo.edu

Always discuss trial participation with your own doctor first.

Locations (35)

Northern Arizona HealthcareFlagstaff, Arizona, United StatesRecruiting
Mayo Clinic ArizonaPhoenix, Arizona, United StatesRecruiting
Keck School of Medicine of USCLos Angeles, California, United StatesRecruiting
Clinical Research InstituteLos Angeles, California, United StatesRecruiting
Desert Physicians Medical GroupPalm Springs, California, United StatesRecruiting
The Neurology GroupPomona, California, United StatesRecruiting
University of Colorado Anschutz Medical CampusAurora, Colorado, United StatesRecruiting
Memorial HealthcareHollywood, Florida, United StatesRecruiting
Mayo Clinic FloridaJacksonville, Florida, United StatesRecruiting
Apple Med ResearchMiami, Florida, United StatesRecruiting
University of MiamiMiami, Florida, United StatesRecruiting
Clinical Trials of New EnglandHyde Park, Massachusetts, United StatesRecruiting

+ 23 more locations — full list on the registry record.

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Source record: clinicaltrials.gov/study/NCT06972056