Condition: Esophageal Varices · Portal Hypertension · Sponsor: Shanghai Zhongshan Hospital
Endoscopic esophageal variceal ligation combined with gastric variceal embolization using tissue glue is currently the first-choice method for preventing rebleeding in patients with cirrhosis and portal hypertension. However, the rebleeding rate remains relatively high. Factors such as extra-luminal vascular bundles in the esophagus and stomach walls, and portosystemic shunts significantly affect the therapeutic outcomes. Therefore, there is an urgent need to develop an individualized treatment model for esophagogastric varices based on the anatomical and hemodynamic characteristics of the varices, to stratify patient risks and provide tailored treatment options. Before the treatment of esophagogastric varices, the vascular characteristics of esophagogastric varices are assessed based on imaging data such as portal venous CT and ultrasound, as well as clinical information. Risk factors influencing bleeding from esophagogastric varices are explored, and an endoscopic and interventional variceal stratification and treatment model is constructed to provide patients with personalized options for endoscopic or interventional therapy. During the treatment of esophagogastric varices, precise endovascular embolization of the source branch vessels of esophagogastric varices is performed based on hemodynamic models. The safety and efficacy of this treatment strategy are verified through randomized controlled clinical trials. After the treatment of esophagogastric varices, the feasib…
This description comes directly from the study's public registry record.
Yiting Wang, Ph.D. · +86-15221919860 · wang.yiting@zs-hospital.sh.cn
xiaoquan huang, M.D. · +86-18801733835 · huang.xiaoquan@zs-hospital.sh.cn
Always discuss trial participation with your own doctor first.
| Southern Medical University Nanfang Hospital | Guangzhou, Guangdong, China | Recruiting |
| The Third Affiliated Hospital of Sun Yat-sen University | Guangzhou, Guangdong, China | Recruiting |
| The First Affiliated Hospital of Nanchang University | Nanchang, Jiangxi, China | Recruiting |
| People's Liberation Army Northern Theater General Hospital | Shenyang, Liaoning, China | Recruiting |
| Qilu Hospital of Shandong University | Jinan, Shandong, China | Recruiting |
| Shandong Provincial Hospital | Jinan, Shandong, China | Recruiting |
| Renji Hospital, Affiliated to Shanghai Jiao Tong University School of Medicine | Shanghai, Shanghai Municipality, China | Recruiting |
| Shanghai Changzheng Hospital | Shanghai, Shanghai Municipality, China | Recruiting |
| Shanghai East Hospital | Shanghai, Shanghai Municipality, China | Recruiting |
| Zhongshan Hospital | Shanghai, Shanghai Municipality, China | Recruiting |
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Source record: clinicaltrials.gov/study/NCT06970509