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Study identifier: NCT06968832 Synced from ClinicalTrials.gov · July 28, 2026
● Recruiting

Project COMET: Massed Prolonged Exposure for PTSD and SUD

Condition: Posttraumatic Stress Disorder (PTSD) · Substance Use Disorders (SUD) · Comorbidity  ·  Sponsor: Rutgers, The State University of New Jersey

PhaseNA
Planned participants168
Who can joinAll sexes, 18 Years to no upper limit
Healthy volunteersNo

About this study

The goal of this clinical trial is to learn if Massed Prolonged Exposure Therapy (M-PE) can improve PTSD symptoms and reduce substance use in adults receiving intensive outpatient (IOP) treatment for substance use disorder (SUD). The main questions it aims to answer are: * Does M-PE reduce PTSD symptoms more effectively than trauma treatment as usual (TAU)? * Does M-PE reduce the number of days participants use substances? * How do patient-centered outcomes (such as depression, suicidal thoughts, and quality of life) differ between M-PE and trauma TAU? * Researchers will compare M-PE to treatment as usual to see if M-PE leads to better mental health and substance use outcomes and lower dropout rates. Participants will: * Attend multiple therapy sessions per week (M-PE) or receive usual care * Complete assessments at baseline, during treatment, end-of-treatment, 1-month, 3-month, and 6-month follow-up * Share feedback through surveys and interviews about their experience in the program

This description comes directly from the study's public registry record.

Talk to the study team

Denise Hien Helen E. Chaney Endowed Chair in Alcohol Studies, Ph.D  ·  848-445-0749  ·  denise.hien@smithers.rutgers.edu

Always discuss trial participation with your own doctor first.

Locations (1)

Gateway Community ServicesJacksonville, Florida, United StatesRecruiting

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Source record: clinicaltrials.gov/study/NCT06968832