Condition: Stroke · Aphasia · Aphasia Following Cerebral Infarction · Sponsor: University of Pennsylvania
The goal of this clinical trial is to determine if Transcranial Magnetic Stimulation (TMS) combined with modified Constraint Induced Language Therapy (mCILT) is an effective treatment for aphasia when delivered in the subacute stage after stroke. The main questions this study aims to answer are: 1. Can TMS combined with mCILT improve overall speech? 2. Can we identify specific behavioral and biological characteristics that would benefit most from the TMS and mCILT treatment? Researchers will compare real TMS to sham (fake) TMS to see whether TMS can treat subacute aphasia. Importantly, this trial will use electric field guided TMS to identify optimal and individualized stimulation intensity and site targeting. Participants will: * Complete a screening and medical intake to determine eligibility * Undergo MRI scans * Participate in 10 consecutive sessions (Monday-Friday) of TMS and mCILT treatment * Complete follow-up assessments immediately and 4 months after treatment
This description comes directly from the study's public registry record.
Leslie Vnenchak, MA, CCC-SLP · 215-964-2502 · leslie.vnenchak@pennmedicine.upenn.edu
Daniela Sacchetti, MS · 215-964-2502 · danielas@pennmedicine.upenn.edu
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| University of Pennsylvania | Philadelphia, Pennsylvania, United States | Recruiting |
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Source record: clinicaltrials.gov/study/NCT06968663