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Study identifier: NCT06967597 Synced from ClinicalTrials.gov · July 28, 2026
● Recruiting

Conservative Versus Proactive Management of Acute Cholecystitis After EUS-guided Transmural Gallbladder Drainage: FUGITIVE Trial (FUGITIVE)

Condition: Acute Cholecystitis  ·  Sponsor: Hospital General Universitario de Alicante

PhaseNA
Planned participants82
Who can joinAll sexes, 18 Years to no upper limit
Healthy volunteersNo

About this study

Patients with gallbladder inflammation (acute cholecystitis) who cannot undergo surgery due to their fragility and surgical risk require a gallbladder drainage. It has been confirmed in previous studies that the gallbladder drainage from the digestive tract is a better alternative, because it has fewer complications than external (percutaneous) gallbladder drainage. However, there are no known studies that demonstrate whether it is better to maintain this drainage indefinitely, or to carry out periodic revisions of the drainage to progressively remove the stones lodged in the gallbladder and remove the drainage once this has been achieved. In this study we aim to compare the clinical evolution of patients who undergo this gallbladder drainage, dividing them into two groups: * One group of patients in whom we maintain a metallic prosthesis or stent, which communicates the gallbladder with the stomach, indefinitely in order to always guarantee a drainage of the bile towards the digestive tract, and thus avoid new episodes of cholecystitis. * Another group of patients who, one month after having undergone drainage, undergo a new procedure to remove the gallbladder lithiasis, until it is empty and without inflammation and we can remove the metal stent, leaving only a very thin plastic catheter to maintain the fistula and thus the bile continues to flow into the digestive tract. More than one procedure may be required to completely clear the gallbladder. Knowledge of whether one…

This description comes directly from the study's public registry record.

Talk to the study team

José Ramón Aparicio Tormo, MD  ·  (0034)965933468  ·  japariciot@gmail.com

Pedro López-Muñoz, MD  ·  (0034)965933468  ·  pedro.lopez8928@gmail.com

Always discuss trial participation with your own doctor first.

Locations (2)

Hospital Universitario Dr Balmis AlicanteAlicante, Alicante, SpainNot Yet Recruiting
Hospital General Universitario Dr. BalmisAlicante, Alicante, SpainRecruiting

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Source record: clinicaltrials.gov/study/NCT06967597