Condition: Alzheimer Disease · Dementia Alzheimer Type · Dementia Alzheimer's Type · Sponsor: Vincent Tay Khwee Soon
Alzheimer's disease (AD), one of the most common causes of dementia in Singapore and the developed world, is a neurodegenerative disorder with high socioeconomic impact. Accumulation of neurotoxic proteins (ie. amyloid, tau) are purported to lead to neuroinflammation, synaptic dysfunction and cognitive decline. The available pharmacotherapy provide limited symptomatic control, modest effect on disease progression with significant risk of side effects. Patients with AD eventually run out of effective pharmacotherapy and deteriorate. Recent evidence implicated the glymphatic system, meningeal lymphatics of the brain, and downstream drainage to the cervical lymphatic system in the accumulation of neurotoxic proteins in AD. This presented the opportunity for extra-cranial intervention, and has since been demonstrated in preclinical models. Based on these development, Xie and colleagues pioneered the deep cervical lymph node to venous bypass (DCLNV-BP) procedure with very promising early outcomes. The observed improvement had been attributed to enhanced clearance of the neurotoxic proteins. Knowledge gap and clinical equipoise remain, and clinical trials are required to understand the safety, mechanism of action, patient selection, and long-term outcomes. In this proof of concept study, the investigators aim to assess safety and preliminary efficacy of DCLNV-BP in AD. An approach using objective clinical assessments, biomarkers and neuroimaging, to assess safety, evaluate prelim…
This description comes directly from the study's public registry record.
Vincent KS Tay, MD, FAMS · +65 6788 8833 · vincent.tay.k.s@singhealth.com.sg
Jeremy MF Sun, MBBS, FAMS · +65 90304976 · jeremy.sun.m.f@singhealth.com.sg
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| Changi General Hospital | Singapore, Singapore | Recruiting |
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Source record: clinicaltrials.gov/study/NCT06965062