Condition: ST-elevation Myocardial Infarction (STEMI) · Microplastics · Nanoplastics · Sponsor: Azienda Ospedaliera "Sant'Andrea"
Air pollution and microplastics pose major public health threats. Emerging data have shown that micro- and nanoplastics (MNPs) are ubiquitous environmental pollutants accumulating in human tissues, triggering inflammation and prothrombotic state. This study will investigate the presence and burden of MNPs within coronary thrombi/thromboaspirate of patients presenting with ST segment elevation acute myocardial infarction (STEMI) undergoing primary percutaneous coronary intervention and their association with cardiac damage, plaque vulnerability, microvascular obstruction, and cardiovascular events. Plaque vulnerability will be explored by optical coherence tomography, while microvascular obstruction will be assessed by bolus thermodilution and cardiac magnetic resonance. Participants will be followed up for 1-year to evaluate whether the presence and the burden of MNPs will be associated with a higher incidence of the cardiovascular events.
This description comes directly from the study's public registry record.
Emanuele Barbato, MD, PhD · +39 0633776115 · emanuele.barbato@uniroma1.it
Clinical Research Unit Cardiology Dept. Sant'Andrea University Hospital · +39 0633778763 · cru.cardiologia@uniroma1.it
Always discuss trial participation with your own doctor first.
| Sant'Andrea University Hospital | Roma, Rome, Italy | Recruiting |
| Department of Environmental Biological and Pharmaceutical Sciences and Technologies, University of Campania "Luigi Vanvitelli | Caserta, Italy | Active Not Recruiting |
| Division of Cardiology, A.O.R.N. "Sant'Anna e San Sebastiano", Caserta, Italy. | Caserta, Italy | Not Yet Recruiting |
| Cardiovascular Department, A.O.U. Policlinico "G. Rodolico - San Marco", University of Catania, Catania, Italy. | Catania, Italy | Not Yet Recruiting |
| Azienda Ospedaliero Universitaria di Ferrara, Cona, Italy | Ferrara, Italy | Not Yet Recruiting |
| Cardiovascular Division, Morgagni-Pierantoni University Hospital, Forlì, Italy. | Forlì, Italy | Not Yet Recruiting |
| Interventional Cardiology Unit, De Gasperis Cardio Center, Niguarda Hospital, Milan, Italy. | Milan, Italy | Not Yet Recruiting |
| Department of Advanced Medical and Surgical Sciences, University of Campania-Luigi Vanvitelli, Naples, Italy. | Naples, Italy | Active Not Recruiting |
| Division of Cardiology, Cardiovascular and Thoracic Department, Città della Salute e della Scienza, Turin, Italy. | Turin, Italy | Not Yet Recruiting |
| Azienda Ospedaliera Integrata Verona, Italy | Verona, Italy | Recruiting |
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Source record: clinicaltrials.gov/study/NCT06965023