Condition: Glioblastoma · IDH Wild-type and STAT3-positive Glioblastoma · Sponsor: Istituto Oncologico Veneto IRCCS
Multicenter, double-blind, placebo-controlled, randomized trial. Patients affected by STAT3 positive newly diagnosed glioblastoma will be eligible. Patients are randomized using a stratified block randomization method with a 1:1 ratio in two arms: • Experimental/Control arm: Concomitant radiotherapy (60 gy in 30 fractions) + temozolomide 75mg/mq + silibinin/placebo 2 sachets/day dissolved in water throughout concomitant treatment followed by temozolomide cp, 150 mg/m2-200mg/m2, g1-5 q28d + silibinin/placebo 2 sachets/day dissolved in water, day 1-28, q28d for 6-12 cycles. Silibinin/Placebo may be continued until disease progression at the discretion of the physician. Patients will be stratified based on: * Type of surgery (complete Vs partial) * MGMT methylation status (methylated Vs non-methylated) * ECOG PS (0-1 Vs 2)
This description comes directly from the study's public registry record.
Giuseppe Lombardi, MD · 0498215888 · giuseppe.lombardi@iov.veneto.it
Always discuss trial participation with your own doctor first.
| IRCCS Istituto delle Scienze Neurologiche di Bologna | Bologna, BO, Italy | Not Yet Recruiting |
| IRST Dino Amadori | Meldola, FC, Italy | Not Yet Recruiting |
| Azienda Ospedaliero Universitaria Policlinico "G. Rodolico - San Marco " | Catania, Italia/Catania, Italy | Not Yet Recruiting |
| Azienda Ospedaliera Universitaria - Careggi | Florence, Italia/FI, Italy | Not Yet Recruiting |
| ARNAS G.Brotzu P.O Armando Businco | Cagliari, Italy/Cagliari, Italy | Not Yet Recruiting |
| USL Nord Ovest Toscana - Livorno | Livorno, Italy/Livorno, Italy | Not Yet Recruiting |
| Ospedale del Mare, ASL Napoli1 Centro | Naples, italy/Napoli, Italy | Not Yet Recruiting |
| Istituto Oncologico Veneto | Padova, Italy/Padova, Italy | Recruiting |
| Istituto Neurologico Nazionale a Carattere Scientifico IRCCS - Fondazione Mondino | Pavia, Italy/Pavia, Italy | Not Yet Recruiting |
| Azienda Ospedaliera Universitaria G.Martino | Messina, ME, Italy | Not Yet Recruiting |
| Istituto Tumori Regina Elena IRCCS | Roma, RM, Italy | Not Yet Recruiting |
| Fondazione Policlinico Universitario Agostino Gemelli IRCCS | Roma, RM, Italy | Not Yet Recruiting |
+ 4 more locations — full list on the registry record.
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Source record: clinicaltrials.gov/study/NCT06964815