Condition: Heart Failure With Reduced Ejection Fraction (HFrEF) · Sudden Cardiac Death · Ventricular Arrhythmia · Sponsor: University of Rochester
This prospective, multicenter, open-label, randomized comparative effectiveness trial, titled CARVTOP-ICD, evaluates the impact of carvedilol versus metoprolol succinate in patients with heart failure with reduced ejection fraction (HFrEF) and an implantable cardioverter defibrillator (ICD). The study will enroll 2,000 participants across 100 U.S. sites and includes an 18-month feasibility phase with 100 participants from 15 sites. Eligible participants must be currently treated with metoprolol succinate and willing to switch to carvedilol, with randomization in a 1:1 ratio. Participants will be followed for up to 3 years, with regular assessments including ICD interrogations, medication adherence, healthcare utilization, and quality of life surveys. The primary endpoint is the first occurrence of any ICD therapy (appropriate or inappropriate), cardiovascular (CV) hospitalization, or CV death. Secondary endpoints include ICD shock burden, healthcare utilization, and patient-reported quality of life. The trial aims to provide high-quality comparative data to address clinical equipoise surrounding the two commonly used beta-blockers in HFrEF management.
This description comes directly from the study's public registry record.
Mehmet Aktas, M.D. · 585-275-5391 · Mehmet_Aktas@URMC.Rochester.edu
Nicole Guerrero, MBA · 0000000000 · nicole.guerrero@heart.rochester.edu
Always discuss trial participation with your own doctor first.
| HonorHealth | Scottsdale, Arizona, United States | Recruiting |
| AdventHealth Redmond | Rome, Georgia, United States | Recruiting |
| AdventHealth Shawnee Mission | Shawnee Mission, Kansas, United States | Recruiting |
| Henry Ford Health System | Detroit, Michigan, United States | Recruiting |
| University of Mossouri | Columbia, Missouri, United States | Recruiting |
| Creighton University Medical Center | Omaha, Nebraska, United States | Recruiting |
| Suny Downstate | Brooklyn, New York, United States | Recruiting |
| New York-Presbyterian Brooklyn Methodist Hospital | Brooklyn, New York, United States | Recruiting |
| University of Rochester Medical Center | Rochester, New York, United States | Recruiting |
| CHRISTUS Trinity Mother Frances Health System | Tyler, Texas, United States | Recruiting |
| Health University of Utah | Salt Lake City, Utah, United States | Recruiting |
| Virginia Commonwealth University | Richmond, Virginia, United States | Recruiting |
+ 1 more locations — full list on the registry record.
Get one email when the public record changes — results posted, or the study's status changes. Nothing else, ever.
We email about this public record only. Unsubscribe anytime with one click. Never medical advice.
This page is independently generated by Eichor from the public ClinicalTrials.gov record and re-synced daily. It is not the sponsor's official website unless claimed. Nothing here is medical advice; eligibility is always determined by the study team — talk to your own doctor first.
Source record: clinicaltrials.gov/study/NCT06964464