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Study identifier: NCT06964269 Synced from ClinicalTrials.gov · July 28, 2026
● Recruiting

Use of Acthar Gel Single-Dose Pre-Filled SelfJectTM Injector in Patients With Moderate-Severe Keratitis and Autoimmune Disease

Condition: Autoimmune Diseases · Dry Eye · Neurotrophic Keratitis  ·  Sponsor: Toyos Clinic

PhasePhase 4
Planned participants20
Who can joinAll sexes, 18 Years to 85 Years
Healthy volunteersYes

About this study

Single-site, open label pilot study of 20 autoimmune patients diagnosed with dry eye demonstrating via the proparacaine challenge some peripheral corneal pain component. At least 16 patients will receive and complete 12 weeks of 80 units of Acthar Gel to be injected subcutaneously twice weekly via Acthar Gel single-dose pre-filled SelfJectTM injector (SelfJect) to assess the effects on subjective sensation of ocular pain, conjunctival and corneal staining, in vivo assessments of corneal nerves as measured by confocal imaging, VAS scales of common neuropathic pain symptoms and comfort of SelfJect will be assessed.

This description comes directly from the study's public registry record.

Talk to the study team

Harley cheney Study Coordinator, Study Coordinator  ·  +616153274015  ·  hcheney@toyosclinic.com

Melissa Toyos, MD, MD  ·  6153274015  ·  mtoyos@toyosclinic.com

Always discuss trial participation with your own doctor first.

Locations (1)

Toyos ClinicNashville, Tennessee, United StatesRecruiting

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Source record: clinicaltrials.gov/study/NCT06964269