Condition: Primary Membranous Nephropathy · Sponsor: Biogen
In this study, researchers will learn more about the use of felzartamab in participants with primary membranous nephropathy, also known as PMN. In people with PMN, autoantibodies build up in the glomeruli of the kidney. Antibodies are proteins that help the body fight off infection. An autoantibody is a type of antibody that mistakenly targets and attacks the body's own tissues. Glomeruli are the filters of the kidney that remove waste and extra fluid from the body. In PMN, the build-up of autoantibodies in the glomeruli causes damage to the kidneys. Kidney damage can lead to too much protein and blood leaking into the urine. High levels of protein in the urine, called proteinuria, are common in people with PMN. Symptoms of PMN can include swelling in the legs and body, tiredness, and high blood pressure. If left untreated, PMN can eventually lead to kidney failure. In this study, researchers will learn more about how a study drug called felzartamab affects people with PMN. Felzartamab is a monoclonal antibody, which means it is an antibody made in a laboratory. Felzartamab can target immune cells that produce autoantibodies, helping to lower their buildup in the kidneys. The main goal of this study is to compare how felzartamab works compared to a drug called tacrolimus. Tacrolimus is another drug given to people with PMN and kidney disease. The main question that researchers want to answer is: * How many participants achieve a complete response after 104 weeks of treatm…
This description comes directly from the study's public registry record.
US Biogen Clinical Trial Center · 866-633-4636 · clinicaltrials@biogen.com
Global Biogen Clinical Trial Center · clinicaltrials@biogen.com
Always discuss trial participation with your own doctor first.
| Apogee Clinical Research, LLC | Huntsville, Alabama, United States | Recruiting |
| The Nephrology Group, Inc. - Fresno | Fresno, California, United States | Recruiting |
| Academic Medical Research Institute | Los Angeles, California, United States | Recruiting |
| UCLA Health Connie Frank Kidney Transplant Center and General Nephrology | Los Angeles, California, United States | Recruiting |
| UCSF Medical Center | San Francisco, California, United States | Recruiting |
| Stanford University | Stanford, California, United States | Recruiting |
| Henry Ford Hospital- A-Basement Research Pharmacy | Detroit, Michigan, United States | Recruiting |
| Elixia Health - Michigan Kidney Consultants, LLC - Elixia - PPDS | Pontiac, Michigan, United States | Completed |
| James J Peters Veterans Administration Medical Center - NAVREF - PPDS | The Bronx, New York, United States | Recruiting |
| ECU Physicians Nephrology and Hypertension | Greenville, North Carolina, United States | Recruiting |
| University Hospitals Cleveland Medical Center | Cleveland, Ohio, United States | Recruiting |
| Knoxville Kidney Center, PLLC | Knoxville, Tennessee, United States | Recruiting |
+ 92 more locations — full list on the registry record.
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Source record: clinicaltrials.gov/study/NCT06962800