Condition: Disorders of Consciousness · Sponsor: Assistance Publique - Hôpitaux de Paris
Following severe brain damage, some individuals lose partial or total awareness of themselves and their environment, falling into a coma that can evolve towards a Disorder of Consciousness (DoC). Accurately diagnosing the depth of consciousness alteration, and thus characterizing the patient's residual state of consciousness, is a real medical challenge, yet crucial for establishing a neurological prognosis, predicting cognitive outcome, and guiding medical decisions. Clinicians attempt to classify DoC patients into different global states (e.g. coma, Unresponsive Wakefulness Syndrome (UWS), Minimally Conscious State (MCS)) depending on their residual level of arousal and awareness. In recent years, the improvement of diagnostic tools and the use of a multimodal approach combining clinical, neurophysiological and neuroimaging examinations, have greatly refined this assessment and revealed the existence of possible discrepancies between clinical observation (e.g. poor consciousness state like UWS) and brain activity (richer, MCS+ type, or even conscious) so-called Cognitive-Motor Dissociation, making it essential to search for any 'hidden cognition' not revealed by the clinical behavioral examination. It is therefore essential to have tools that can not only probe consciousness level, but also provide a detailed profile of patients' residual cognitive abilities - such as language, attention or memory - which are essential dimmensions of conscious experience and shape waking c…
This description comes directly from the study's public registry record.
Benjamin Rohaut, MD PhD · 01 84 82 78 88 · benjamin.rohaut@icm-institute.org
Thomas Andrillon, PhD · 06 44 82 00 32 · thomas.andrillon@icm-institute.org
Always discuss trial participation with your own doctor first.
| APHP, Pitié-Salpêtrière Hospital, Department of Anesthesia and Intensive Care, NeuroSurgery ICU | Paris, France | Recruiting |
| APHP, Pitié-Salpêtrière Hospital, Department of Neurology, Neuro-ICU | Paris, France | Recruiting |
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