← Eichor
Study identifier: NCT06959108 Synced from ClinicalTrials.gov · July 28, 2026
● Recruiting

Clinical Trial Comparing Induction Treatment With EGFR-ADC MRG003 Alone or in Combination With the Anti PD1 Pucotenlimab, Followed by Radiochemotherapy in Locally Advanced Squamous Cell Cancers of the Head and Neck

Condition: Locally Advanced Head and Neck Squamous Cell Carcinoma  ·  Sponsor: Groupe Oncologie Radiotherapie Tete et Cou

PhasePhase 2
Planned participants106
Who can joinAll sexes, 18 Years to 75 Years
Healthy volunteersNo

About this study

The primary objective of this study is to compare the objective response rate (ORR) of patients with LA-HNSCC, treated with induction of EGFR-ADC MRG003 and anti PD-1 Pucotenlimab versus EGFR-ADC MRG003 alone before chemoradiotherapy. People eligible to participate in this study must be between the ages of 18 and 75 and have locally advanced squamous cell carcinoma of the head and neck requiring treatment with chemoradiotherapy (cisplatin combined with radiotherapy). Half of the research participants will receive MRG003 alone as induction before radiochemotherapy and the other half will receive MRG003 combined with pucotenlimab as induction before radiochemotherapy, then pucotenlimab as adjuvant\* after radiochemotherapy.

This description comes directly from the study's public registry record.

Talk to the study team

Marceline EMGOUE  ·  02 42 06 02 56  ·  marceline.emgoue@gortec.fr

Laura SINIGAGLIA  ·  02 42 06 01 86

Always discuss trial participation with your own doctor first.

Locations (1)

Gustave RoussyVillejuif, FranceRecruiting

Follow this study

Get one email when the public record changes — results posted, or the study's status changes. Nothing else, ever.

We email about this public record only. Unsubscribe anytime with one click. Never medical advice.

Is this your study? This page was generated automatically from the public registry record. Sponsors can claim it — free — to add branding and verified contact routing. Claim this page →

This page is independently generated by Eichor from the public ClinicalTrials.gov record and re-synced daily. It is not the sponsor's official website unless claimed. Nothing here is medical advice; eligibility is always determined by the study team — talk to your own doctor first.

Source record: clinicaltrials.gov/study/NCT06959108