Condition: Encephalopathy · Psychosis · Impaired Consciousness · Sponsor: Charite University, Berlin, Germany
A variety of antineuronal antibodies have been detected in the cerebrospinal fluid (CSF) of patients with neurological diseases. This raises the question of whether these antibodies are disease-specific or merely an epiphenomenon of inflammatory processes in the brain. The registry was established with the following objectives: \[1\] Are antineuronal antibodies much more common than previously thought in various neurological disorders for which the etiology has not yet been elucidated? \[2\] Can further correlations, such as those between HSV infection and NMDA receptor autoimmunity, be identified? \[3\] Are these antibodies mainly non-specific epiphenomena or are they crucial for the pathogenesis? \[4\] What is the clinical course of patients with antineuronal antibodies and their response to therapy? These questions will be addressed in a broad immunohistological screening of a large number of CSF samples and a clinical database of patients with neurological disorders.
This description comes directly from the study's public registry record.
Markus Schuelke, MD · +49 30 450 566112 · markus.schuelke@charite.de
Marc Nikolaus, MD · +49 30 450 566112 · marc.nikolaus@charite.de
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| Charité - Universitätsmedizin Berlin | Berlin, State of Berlin, Germany | Recruiting |
| Universität Ulm | Ulm, Germany | Recruiting |
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Source record: clinicaltrials.gov/study/NCT06958341