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Study identifier: NCT06957691 Synced from ClinicalTrials.gov · July 28, 2026
● Recruiting

Proof-of-Concept Trial to Assess the Efficacy and Safety of Fezolinetant in Improving Vasomotor Symptoms in Men With Prostate Cancer Undergoing Androgen Deprivation Therapy

Condition: Prostate Cancer · Prostate Cancer (Adenocarcinoma) · Prostate Cancer Metastatic Disease  ·  Sponsor: Shehzad Basaria, M.D.

PhasePhase 2
Planned participants60
Who can joinMale, 40 Years to no upper limit
Healthy volunteersNo

About this study

The goal of this clinical trial is to learn if fezolinetant can treat hot flashes (vasomotor symptoms) in men with prostate cancer undergoing androgen deprivation therapy. The main questions it aims to answer are: * Does fezolinetant improve the frequency and severity of hot flashes? * Does fezolinetant cause any harm to the liver? * Does fezolinetant improve quality of life, sleep quality, fatigue, mood, sexual function, and metabolic parameters? Researchers will compare how people respond to fezolinetant versus a placebo, which does not contain any active medicine. Participants will: * Take fezolinetant or a placebo every day for 4 weeks * Visit the clinic once every 2 weeks for checkups and tests * Keep a diary of the number of times and intensity that they experience hot flashes

This description comes directly from the study's public registry record.

Talk to the study team

Caroline Veteri  ·  617-525-8407  ·  cveteri@bwh.harvard.edu

Always discuss trial participation with your own doctor first.

Locations (1)

Brigham and Women's HospitalBoston, Massachusetts, United StatesRecruiting

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Source record: clinicaltrials.gov/study/NCT06957691