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Study identifier: NCT06956300 Synced from ClinicalTrials.gov · July 28, 2026
● Recruiting

TMS for Cognitive Decline in Aging and Preclinical AD

Condition: Prodromal Alzheimer's Disease · Preclinical Alzheimer's Disease · Healthy Aging  ·  Sponsor: Massachusetts General Hospital

PhaseNA
Planned participants80
Who can joinAll sexes, 40 Years to 99 Years
Healthy volunteersYes

About this study

In this research study we want to learn more about the effects of non-invasive brain stimulation on motivation, memory, and brain-network function in cognitively unimpaired older adults and individuals with preclinical Alzheimer's disease. This study will use a form of non-invasive brain stimulation called repetitive Transcranial Magnetic Stimulation (rTMS). rTMS will slightly alter activity in an area of your brain that controls cognition. Changes resulting from this stimulation will be measured with behavioral tests, as well as by taking brain images with Magnetic Resonance Imaging (MRI). Participants will come in for one baseline visit followed by 10 days of daily rTMS study visits (Monday through Friday) and an evaluation visit. Then, there will be a 2-week break. After this break, they will return for another baseline visit, an additional 10 days of rTMS, and a final evaluation visit.

This description comes directly from the study's public registry record.

Talk to the study team

Alexandra Touroutoglou, PhD  ·  6176436348  ·  atouroutoglou@mgh.harvard.edu

Jordan Walter, BA  ·  6177266207  ·  jwalter2@mgh.harvard.edu

Always discuss trial participation with your own doctor first.

Locations (1)

Massachusetts General HospitalBoston, Massachusetts, United StatesRecruiting

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Source record: clinicaltrials.gov/study/NCT06956300