Condition: Myocardial Infarction · Cardiogenic Shock · Sponsor: Efferon JSC
Cardiogenic shock is the most severe manifestation of acute heart failure and remains the leading cause of death in patients hospitalised with acute myocardial infarction. Cardiogenic shock is a well-known and potent trigger of the immune response, ischemia/reperfusion organ damage, hemolysis and release of free hemoglobin. The activation of immune cells leads to the release of cytokines and inflammatory mediators such as IL-6, IL-8, activated complement and others. As a result of myocardial ischaemia and reperfusion injury, a multiorgan dysfunction syndrome may develop. The Efferon CT hemoadsorption device effectively removes cytokines and other pro-inflammatory molecules (≤55 kDa). This study evaluates whether this blood-filtering therapy can prevent organ failure in acute myocardial infarction patients with cardiogenic shock by eliminating inflammation-inducing mediators.
This description comes directly from the study's public registry record.
Alexandr Shelehov-Kravchenko, PhD, MD · +79636564765 · alexandr.shelehov@gmail.com
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| Tomsk NRMC Cardiology Research Institute | Tomsk, Russia | Recruiting |
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Source record: clinicaltrials.gov/study/NCT06955936