Condition: GERD · Sponsor: Asian Institute of Gastroenterology, India
Peroral Endoscopic Myotomy (POEM) is a well-established treatment for achalasia; however, it is frequently associated with gastroesophageal reflux disease (GERD), with many patients developing LA grade B or higher esophagitis. Proton pump inhibitors (PPIs) like Esomeprazole are the standard treatment, but Vonaprazan, a potassium-competitive acid blocker (P-CAB), offers superior acid suppression and may provide enhanced healing in post-POEM reflux esophagitis. Primary Objective: • To compare the healing rates of LA grade B or higher reflux esophagitis at 8 weeks in patients receiving Vonaprazan 20 mg versus Esomeprazole 40 mg. Secondary Objectives * To assess improvement in reflux symptoms using the GERD-Q score at 8 weeks. * To evaluate the incidence of adverse events in each treatment group.
This description comes directly from the study's public registry record.
Rajesh Goud Mr Maragoni, M.Pharm · 04023378888 · rajeshgoud761@gmail.com
Zaheer Nabi Dr Mohammed, MD DNB · 04023378888 · zaheernabi1978@gmail.com
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| Asian Institute of Gastroenterology /Aig Hospitals | Hyderabad, Telangana, India | Recruiting |
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Source record: clinicaltrials.gov/study/NCT06955520