Condition: Triple Negative Breast Cancer · Sponsor: QIAO LI
Trilaciclib is a highly potent, selective, and reversible CDK4/6 inhibitor that protects bone marrow by protecting hematopoietic stem cells and progenitor cells (HSPCs) during systemic chemotherapy. The proliferation and differentiation of HSPCs are highly dependent on the CDK4/6 signaling pathway, and when exposed to the appropriate dose of treacilil, they will be blocked in the G1 phase of the cell cycle, thus avoiding the killing of cell cycle-specific chemotherapy drugs. This is an open, single-arm, multicenter Phase II clinical study. Newly diagnosed TNBC patients with T1c N1-2 or T2-4 N0-2 will be screened according to the inclusion criteria. Fifty patients meeting the inclusion criteria will sign informed consent letters and receive neoadjuvant therapy with Trilaciclib + anti-PD-1 antibody + Paclitaxel-albumin + carboplatin. To evaluate the synergistic effect of Trilaciclib on bone marrow protection and anti-tumor therapy.
This description comes directly from the study's public registry record.
Binghe Xu · 86-10-87788495 · xubinghe@medmail.com.cn
Qiao Li · 86-10-87788120 · liqiaopumc@qq.com
Always discuss trial participation with your own doctor first.
| National Cancer Center/National Clinical Research Center for Cancer/Cancer Hospital | Beijing, China | Recruiting |
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Source record: clinicaltrials.gov/study/NCT06955156