Condition: Ovarian Cancer · Sponsor: Tongji Hospital
Fluzoparib has been approved for the first-line maintenance treatment of advanced ovarian cancer in the full population . Previous studies have demonstrated that anti-angiogenic agents enhance tumor cell sensitivity to PARP inhibitors . In vitro evidence suggests that low-carbohydrate culture conditions may restore PARP inhibitor sensitivity in HRD-negative tumor cells. This study aims to validate the survival benefits of fluzoparib combined with bevacizumab in HRD-positive ovarian cancer patients during first-line maintenance therapy and explore the efficacy of fluzoparib combined with a dietary intervention in HRD-negative populations.
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| Tongji Hospital | Wuhan, Hubei, China | Recruiting |
| Tongji Hospital | Wuhan, Hubei, China | Recruiting |
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Source record: clinicaltrials.gov/study/NCT06954584