Condition: Triple Negative Breast Cancer · Sponsor: Queen Mary University of London
The DIAMOND study is being carried out to evaluate if Datopotamab deruxtecan (Dato-DX) in combination with Durvalumab is more effective than Dato-DXd alone in treating PDL1-negative advanced or metastatic triple negative breast cancer (TNBC). Globally, breast cancer is the most common malignancy in women and the second most common cancer overall. The term TNBC is used to define tumours that do not express oestrogen receptors, progesterone receptors and HER2 receptors. TNBC comprises 10 -15% of all breast cancers. It remains the subtype with poorest outcome and there is a significant need to develop new therapies for this group of patients especially. Moreover, the PDL1-negative tumour has demonstrated no benefit from standard 1st line treatment of chemotherapy plus immune checkpoint inhibitors.
This description comes directly from the study's public registry record.
Peter Schmid, MD PhD, FRCP · +44(0)20 7882 8764 · bci-diamond@qmul.ac.uk
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| Barts Cancer Institute, Centre of Experimental Cancer Medicine | London, United Kingdom | Not Yet Recruiting |
| Barts Health NHS Trust | London, United Kingdom | Recruiting |
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Source record: clinicaltrials.gov/study/NCT06954480