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Study identifier: NCT06953674 Synced from ClinicalTrials.gov · July 28, 2026
● Recruiting

Saline Versus Balanced Crystalloid in Traumatic Brain Injury

Condition: Traumatic Brain Injury (TBI) Patients  ·  Sponsor: University of Louisville

PhasePhase 3
Planned participants600
Who can joinAll sexes, 18 Years to no upper limit
Healthy volunteersNo

About this study

The goal of this clinical trial is to determine which crystalloid (saline or balanced) should be used in the critical management of Traumatic Brain Injury (TBI) in moderate or severe TBI patients. This trial will determine whether the use of saline or balanced crystalloids is associated with improved outcomes in TBI patients. Participants will 1. be given fluids through the veins, either saline or balanced fluid will be given. 2. From the first day to the day 14 of the hospitalization (or discharge, whichever comes first), vital signs, laboratory values, treatments given, and other medical data will be collected from the medical record. 3. Six months later, your final disability, if any, will be assessed during your follow-up with a doctor. It involves answering a short survey that will take about 5 minutes or less.

This description comes directly from the study's public registry record.

Talk to the study team

Mechelle Kaufman, BSN, RN  ·  502-588-2329  ·  mechelle.kaufman@louisville.edu

Akshitkumar Mistry, M.D.  ·  a.mistry@uoflhealth.org

Always discuss trial participation with your own doctor first.

Locations (1)

University of Louisville HospitalLouisville, Kentucky, United StatesRecruiting

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Source record: clinicaltrials.gov/study/NCT06953674