Condition: Vasoplegia Syndrome · Vasoplegia · Cardiac Surgical Procedures · Sponsor: Guillaume BESCH
Background: Acute circulatory failure, often presenting as arterial hypotension, is a major contributor to postoperative morbidity and mortality. Accurate blood pressure (BP) monitoring is essential for timely therapeutic intervention, particularly in patients undergoing major surgery. Among invasive BP measurement sites, the radial artery is commonly used due to its accessibility and ease of catheterization. However, physiologically, the radial artery may underestimate central arterial pressure compared to the femoral artery, especially in patients receiving vasopressors or in critical conditions. This discrepancy can lead to overtreatment with vasopressors and associated complications. Current literature on the accuracy of radial versus femoral BP monitoring is outdated and based solely on observational studies. There is a lack of high-quality randomized data to inform clinical guidelines. Hypothesis: Femoral arterial pressure monitoring, by offering more accurate hemodynamic data, reduces the need for vasopressor support, particularly norepinephrine, compared to radial artery monitoring. Primary Objective: To compare the effect of femoral versus radial invasive BP monitoring on the proportion of patients requiring norepinephrine from anesthetic induction to postoperative day 7 (D7) following elective cardiac surgery. Norepinephrine treatment is defined by continuous intravenous administration of norepinephrine for more than 1 minute. Secondary Objectives : To compare t…
This description comes directly from the study's public registry record.
Guillaume Besch, M.D., Ph.D. · +333 812 189 58 · gbesch@chu-besancon.fr
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| Centre Hospitalier Universitaire de Besançon | Besançon, France | Recruiting |
| Centre Hospitalier Universitaire de Dijon | Dijon, France | Recruiting |
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Source record: clinicaltrials.gov/study/NCT06952907