Condition: Endometrial Cancer · Sponsor: Merck Sharp & Dohme LLC
Researchers are looking for new ways to treat people with proficient mismatch repair (pMMR) endometrial cancer (EC) that is advanced or recurrent. * EC is a type of cancer that starts in the tissues inside the uterus (womb) * pMMR indicates that certain normal proteins are present in the cancer cells * Advanced means the cancer has spread locally or to other parts of the body (metastatic) and cannot be removed with surgery * Recurrent means the cancer came back after surgery Sacituzumab tirumotecan (also known as sac-TMT) and pembrolizumab are the study medicines. Sac-TMT is an antibody drug conjugate (ADC). An ADC attaches to specific targets on cancer cells and delivers treatment to destroy those cells. The goal of this study is to learn if people who receive sac-TMT with pembrolizumab live longer and without the cancer getting worse compared to people who receive pembrolizumab alone.
This description comes directly from the study's public registry record.
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| University of South Alabama, Mitchell Cancer Institute ( Site 6033) | Mobile, Alabama, United States | Recruiting |
| Alaska Women's Cancer Care ( Site 6036) | Anchorage, Alaska, United States | Recruiting |
| CHAO Family Comprehensive Cancer Center and Ambulatory Care ( Site 5014) | Irvine, California, United States | Recruiting |
| University of California, Irvine (UCI) Health - UC Irvine Medical Center ( Site 6020) | Orange, California, United States | Recruiting |
| John Muir Health Cancer Center ( Site 6028) | Walnut Creek, California, United States | Recruiting |
| Yale University School of Medicine ( Site 6009) | New Haven, Connecticut, United States | Recruiting |
| MedStar Washington Hospital Center ( Site 5005) | Washington D.C., District of Columbia, United States | Recruiting |
| Florida Cancer Specialists - South ( Site 7003) | Fort Myers, Florida, United States | Recruiting |
| UF Health Davis Cancer Pavilion and Shands Med Plaza ( Site 6026) | Gainesville, Florida, United States | Recruiting |
| Mount Sinai Braman Comprehensive Cancer Center ( Site 6031) | Miami Beach, Florida, United States | Recruiting |
| AdventHealth Orlando-AdventHealth Medical Group Gynecological Oncology ( Site 6002) | Orlando, Florida, United States | Recruiting |
| Florida Cancer Specialists ( Site 7002) | St. Petersburg, Florida, United States | Recruiting |
+ 249 more locations — full list on the registry record.
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Source record: clinicaltrials.gov/study/NCT06952504