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Study identifier: NCT06952413 Synced from ClinicalTrials.gov · July 28, 2026
● Recruiting

Study of the Efficacy and Safety for Rituximab in Myalgia Encephalomyelitis/Chronic Fatigue Syndrome (ME/CFS)

Condition: Myalgia Encephalomyelitis/Chronic Fatigue Syndrome (ME/CFS)  ·  Sponsor: National Center of Neurology and Psychiatry, Japan

PhasePhase 2
Planned participants30
Who can joinAll sexes, 18 Years to 65 Years
Healthy volunteersNo

About this study

The efficacy and safety of rituximab on ME/CFS symptoms after administration to patients with myalgic encephalomyelitis/chronic fatigue syndrome will be compared in an exploratory, placebo-controlled, double-blind fashion. In the subsequent secondary evaluation period, subjects who received rituximab in the primary evaluation period will receive placebo, and the timing and duration of rituximab's effect will be explored throughout the entire evaluation period. Subjects who received placebo during the primary evaluation period will receive rituximab during the secondary evaluation period to explore changes in endpoints before and after switching from placebo to rituximab in the same subjects.

This description comes directly from the study's public registry record.

Talk to the study team

Takami Ishizuka, PhD  ·  +081-42-341-2711  ·  tmc-crso@ncnp.go.jp

Always discuss trial participation with your own doctor first.

Locations (1)

National Center of Neurology and PsychiatryKodaira, Tokyo, JapanRecruiting

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Source record: clinicaltrials.gov/study/NCT06952413