Condition: Hypotension · Sponsor: Nanfang Hospital, Southern Medical University
High-risk populations, particularly elderly individuals and patients with cardiovascular comorbidities, exhibit markedly elevated incidences of postoperative myocardial injury (MINS), acute kidney injury (AKI), and mortality. Intraoperative hypotension (IOH), a pervasive clinical phenomenon affecting 40%-90% of surgical cases, Substantial observational evidence links IOH severity/duration to ischemic organ injuries (MINS, AKI) and long-term morbidity.Nevertheless, inherent limitations of observational designs-particularly residual confounding-preclude definitive causal inferences. Notably, randomized controlled trials (RCTs) investigating goal-directed hemodynamic interventions demonstrate inconsistent clinical benefits, underscoring the imperative to clarify causal mechanisms between IOH and organ injury. This causal ambiguity arises from two unresolved scientific questions: (1) Threshold personalization deficit; (2) Therapeutic strategy limitations. In light of current evidence, perioperative hypotension management demands personalized strategies, the investigators propose a multicenter randomized controlled trial (RCT) that aims to clarify the clinical benefits of individualized blood pressure management.
This description comes directly from the study's public registry record.
Ke-Xuan Liu, MD · 13710684096 · liukexuan705@163.com
Shuang-Jie Cao, MD · 13651119431 · caosjie1994@126.com
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| Guangzhou First People's Hospital | Guangzhou, Guangdong, China | Active Not Recruiting |
| Nanfang Hospital, Southern Medical University | Guangzhou, Guangdong, China | Recruiting |
| The Affiliated Panyu Central Hospital of Guangzhou Medical University | Guangzhou, Guangdong, China | Recruiting |
| The Third People's Hospital of Shenzhen | Shenzhen, Guangdong, China | Not Yet Recruiting |
| The Fifth Affiliated Hospital of Sun Yat-sen University | Zhuhai, Guangdong, China | Not Yet Recruiting |
| The First Affiliated Hospital of Xi'an Jiaotong University | Xi’an, Shanxi, China | Not Yet Recruiting |
| Sir Run Run Shaw Hospital | Hangzhou, Zhejiang, China | Not Yet Recruiting |
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Source record: clinicaltrials.gov/study/NCT06952387