Condition: Non Small Cell Lung Cancer · Immune Checkpoint Inhibitors (ICIs) · Sponsor: Second Xiangya Hospital of Central South University
The CR1STAL-Adaptive study is a randomized, open-label, phase II multicenter interventional trial designed to evaluate the safety and efficacy of Ivonescimab (PD-1/VEGF bispecific antibody) combined with docetaxel versus standard treatment in patients with advanced NSCLC who have achieved long-term benefit from first-line immune checkpoint inhibitors (ICIs), but are ctDNA-MRD positive. Building upon insights from previous CR1STAL study (NCT05198154), the CR1STAL-Adaptive study supports the development of precision-guided, adaptive treatment strategies to delay progression and improve outcomes in NSCLC patients with a long-term response to immunotherapy. It represents a step forward in integrating dynamic molecular monitoring with individualized intervention strategies in the era of immunotherapy.
This description comes directly from the study's public registry record.
Fang Wu, MD, PhD · +86 13574858332 · wufang4461@edu.csu.cn
Always discuss trial participation with your own doctor first.
| Hunan Cancer Hospital | Changsha, China | Not Yet Recruiting |
| The Second Xiangya Hospital of Central South University | Changsha, China | Recruiting |
| The Third Hospital of Changsha | Changsha, China | Not Yet Recruiting |
| Xiangya Hospital of Central South University | Changsha, China | Not Yet Recruiting |
| Changsha Central Hospital | Changsha, China | Not Yet Recruiting |
| The First Hospital of Changsha | Changsha, China | Not Yet Recruiting |
| The Third Xiangya Hospital of Central South University | Changsha, China | Not Yet Recruiting |
| Army Medical Center (Daping Hospital) | Chongqing, China | Not Yet Recruiting |
| Guiyang Public Health Clinical Center | Guiyang, China | Not Yet Recruiting |
| Faculty of Medicine, The Chinese University of Hong Kong | Hong Kong, China | Not Yet Recruiting |
| Kiang Wu Hospital, Macao | Macao, China | Not Yet Recruiting |
| The First Affiliated Hospital of Nanchang University | Nanchang, China | Not Yet Recruiting |
+ 8 more locations — full list on the registry record.
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Source record: clinicaltrials.gov/study/NCT06951646