● Recruiting

A Study to Evaluate the Safety and Efficacy of Two Dose Levels of ONO-4578 With Opdivo®, in Combination With mFOLFOX6 and Bevacizumab Versus Standard of Care in Participants With Non-MSI-H/dMMR, PD-L1 Positive Advanced Colorectal Cancer

Condition: Colorectal Cancer · Sponsor: Ono Pharmaceutical Co., Ltd.

PhasePhase 2

Planned participants144

Who can joinAll sexes, 18 Years to no upper limit

Healthy volunteersNo

About this study

The purpose of this study is to evaluate the safety and efficacy of two dose levels of ONO-4578 with Opdivo® when added to mFOLFOX6 and bevacizumab versus SOC as first-line treatment for advanced CRC.

This description comes directly from the study's public registry record.

Talk to the study team

North America Clinical Trial Support Desk · +18665877745(Toll-Free) · clinical_trial@ono-pharma.com

International Clinical Trial Support Desk · +17162141777(Standard) · clinical_trial@ono-pharma.com

Always discuss trial participation with your own doctor first.

Locations (39)

Mayo Clinic Arizona	Phoenix, Arizona, United States	Recruiting
USC Norris Comprehensive Cancer Center	Los Angeles, California, United States	Recruiting
Rocky Mountain Cancer Centers, LLP	Lone Tree, Colorado, United States	Recruiting
Mayo Clinic Florida	Jacksonville, Florida, United States	Recruiting
Advent Health	Orlando, Florida, United States	Recruiting
May Clinic Rochester	Rochester, Minnesota, United States	Recruiting
The Ohio State University Comprehensive Cancer Center	Columbus, Ohio, United States	Recruiting
Thomas Jefferson University, Sidney Kimmel Cancer Center	Philadelphia, Pennsylvania, United States	Recruiting
Baylor Scott & White Medical Center	Temple, Texas, United States	Recruiting
Virginia Oncology Associates	Norfolk, Virginia, United States	Recruiting
Blue Ridge Cancer Care	Salem, Virginia, United States	Recruiting
The Ottawa Hospital Cancer Centre	Ottawa, Ontario, Canada	Recruiting

+ 27 more locations — full list on the registry record.

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Source record: clinicaltrials.gov/study/NCT06948448